1. Long-distance runners
2. Marching soldiers
3. Hikers
Causes:
1. Mechanical stress on red blood cells
2. Increased blood flow and pressure in the feet
3. Footstrike trauma
Symptoms:
1. Dark urine (hemoglobinuria)
2. Fatigue
3. Pale skin
4. Shortness of breath
5. Mild jaundice
Treatment:
1. Rest and ice
2. Compression and elevation of affected limbs
3. Pain management
4. Monitoring of kidney function
5. Avoiding activities that trigger the condition
Prevention:
1. Gradual increase in exercise intensity and duration
2. Proper footwear and orthotics
3. Running on softer surfaces
4. Strengthening foot and ankle muscles
Complications:
1. Anemia
2. Kidney damage
3. Chronic hemolysis
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